Cyclodextrins (CDs)
Naturally occurring multifunctional compounds with more than 120 pharmaceutical products on the market. Furthermore, several CDs received GRAS status, making them available for the food industry.
CarboHyde
Our team consists of a small group of seasoned scientists with over 50 years of cumulative experience in the field of carbohydrate chemistry, analysis and pharmaceutical development.
The benefits of cyclodextrins
Bioavailability enhancement
Cyclodextrins improve drug solubility and dissolution rate. This enhancement increases the bioavailability of poorly soluble compounds, optimizing their therapeutic effects
Beyond bioavailability enhancement
Cyclodextrins effectively mask unpleasant tastes of drugs, improving palatability. Additionally, they enhance stability by encapsulating sensitive compounds, safeguarding them from degradation.
The benefits of CarboHyde
Cost Efficiency, fast development timeline
Our dedicated team offer cost-efficient solutions ensured by established infrastructure, resources, agile methodologies, and streamlined processes.
Flexibility and Scalability
We offer adaptable solutions that can swiftly adjust to varying project scopes and requirements, showcasing remarkable flexibility, with scalable capabilities, ensuring seamless expansion or reduction of resources as needed.
Main phases of our Formulation service
Based on the API’s aimed application, and limitations, various CDs will be selected for the feasibility study
After completing the feasibility study proposed compositions are optimized.
Feasibility study
Formulation development
Phase 1
Pre-formulation
We perform a high-throughput screening of CDs. The in vitro solubilizing efficiency of various CDs will be studied.
Phase 1
Method selection
Various methods will be tested with the selected CDs. The impact of pH effects is also evaluated.
Phase 2
Composition optimization
Various FDA-approved excipients will be tested to further enhance the advantageous properties of CDs.
Phase 2
Stability studies
The prepared complexes and products will be stored at different conditions for studying the stability properties.
Phase 3
Phase-solubility study
The complexation efficiency of selected CDs will be calculated.
Phase 3
Technology transfer
Process transfer is described to ensure seamless scale-up in GMP environment.
Accepted delivery routes for pharma cyclodextrins according to EMEA:
You can check our draft SoW to perform a Feasibility study with your API.
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